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020 _a9789814774529
040 _aB-IKIAM
041 _aeng
082 _a571.96
245 _aInmune Aspects of Biopharmaceuticals and Nanomedicines
_cRaj Bawa; János Szebeni; Thomas J. Webster; Gerald F. Audette
260 _aUSA
_bPan Stanford Publishing
_c2018
300 _a994 p.
_c22 cm.
505 _aCurrent Immune Aspects of Biologics and Nanodrugs: An Overview - Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox - Immunotherapy and Vaccines - Site-Specific Antibody Conjugation for ADC and Beyond - Current Understanding of Interactions between Nanoparticles and the Immune System - Auto-antibodies as Biomarkers for Disease Diagnosis - The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers - Anti-PEG Immunity Against PEGylated Therapeutics - Complement Activation: Challenges to Nanomedicine Development - Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation - Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols - Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms
650 0 _aImmune
650 0 _aNanomedicines
650 0 _aBiopharmaceuticals
942 _2ddc
_aB-IKIAM
_b25-3-2021
_cBK
_zbv
999 _c2104
_d2104