Inmune Aspects of Biopharmaceuticals and Nanomedicines
Raj Bawa; János Szebeni; Thomas J. Webster; Gerald F. Audette
- USA Pan Stanford Publishing 2018
- 994 p. 22 cm.
Current Immune Aspects of Biologics and Nanodrugs: An Overview - Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox - Immunotherapy and Vaccines - Site-Specific Antibody Conjugation for ADC and Beyond - Current Understanding of Interactions between Nanoparticles and the Immune System - Auto-antibodies as Biomarkers for Disease Diagnosis - The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers - Anti-PEG Immunity Against PEGylated Therapeutics - Complement Activation: Challenges to Nanomedicine Development - Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation - Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols - Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms